Preliminary Scientific Programme

Courses

Saturday, September 14, 2019

Course: Inhibitors of Protein Kinases – thermodynamics of protein-ligand interaction

  9:00 – 13:00      lectures (4×60),

15:00 – 19:00      Demonstrations

 

Sunday, September 15, 2019

Course: Inhibitors of Protein Kinases – structural properties and in silico analysis on known and unknown yet structures

  9:00 – 13:00      lectures (4×60)

13:00 – 17:00      training on Web-services.

 

 

 

10th IPK 2019

(September 14-19, 2019)

Preliminary program

 

Sunday, September 15, 2019

14:00 – 17:00      registration

14:00 – 17:00      setting-up posters, including those selected for short
                               oral presentation

 

 

Keynote Lectures                                    
17:00 – 18:45     

Chair: Doriano Fabbro

  • 17:00 – 17:15  Doriano Fabbro and Jarek Poznanski: Introductory
                               notes
  • 17:15 – 18:00  Alex Wlodawer: The importance of the non-catalytic
                               domains of Janus kinases
  • 18:00 – 18:45  Susan Taylor: PKA Dynamic Switches and
                               Disease                                          

 

19:00 – 22:00   Reception

 

Monday, September 16, 2019

Fundamental function of protein kinases                                   
08:30 – 10:30

Chair: Stefan Knapp

  • 08:30 – 09:00  Tomasz Sarnowski: Targeting of chromatin
                               remodeling complexes and metabolome-related
                               kinases in cancer
  • 09:00 – 09:30  Alexandra Newton: Protein Kinase C Unbalanced:
                               loss vs gain of function mutations in disease
  • 09:30 – 10:00  Short talk
  • 10:00 – 10:30  Vincent Tagliabracci: Phosphorylation of secreted
                               proteins by a new family of kinases.

 

10:30 – 11:00      Coffee break

 

Kinases in infectious diseases                                                         
11:00 – 12:30

Chair: Christian Doerig

  • 11:00 – 11:30   Christian Doerig: Kinome-wides assessment of host
                                cell response to intracelluer pathogens
  • 12:00 – 12:30  Short talk
  • 11:30 – 12:00   Andrew Tobin: Chemical genetic approaches to
                                defining the function of phospho-signalling
                                cascades.

 

12:30 – 14:00   Lunch

 

Kinases in infectious diseases                                                         
14:00 – 15:30

Chair: Christian Doerig

  • 14:00 – 14:30  Jeremy Mottram: Title TBA
  • 14:30 – 15:00  Short talk
  • 15:00 – 15:30  Eileen Kennedy: Title TBA

 

15:30 – 16:00         Coffee break

 

Kinases in infectious diseases                                                         
16:00 – 17:30

Chair: Christian Doerig/Alexandra Newton

  • 16:00 – 16:30  Christophe Grangeasse: Title
  • 16:30 – 17:00  Laurent Meijer: Title
  • 17:00 – 17:30  Lightning Talks

 

18:00 – 21:00   poster session and refreshments or Excursion
                              with dinner

 

 

 

Tuesday, September 17, 2019

Computational Technologies for kinases and drug discovery                    
08:30
– 10:30

Chair: Michal Vieth

  • 08:30 – 09:00  Jon Erickson: Computational approaches to kinase
                               discovery, potential discovery story
  • 09:00 – 09:30  Natasja Brooijmans: Free energy methods in
                               advancing kinase projects
  • 09:30 – 10:00  Short talk
  • 10:00 – 10:30  Krzysztof Pawlowski: Novel kinase and pseudokinase
                               families throughout the tree of life. Structural
                               bioinformatics view on evolution of a superfamily

 

10:30 – 11:00      Coffee break

 

Computational Technologies for kinases and drug discovery                      
11:00
– 12:30

Chair: Michal Vieth

  • 11:00 – 11:30  Benoit Roux: Kinetics of kinase inhibitor binding
  • 11:30 – 12:00  Short talk
  • 12:00 – 12:30  Gerhard Mueller: Optimizing binding kinetic
                               signatures of kinase inhibitors: facts or fantasy?

 

12:30 – 14:00   Lunch

 

Kinase target biology                                                                           
14:00-15:30

Chair: Alexndra Newton

  • 14:00 – 14:30  Lorenzo Pinna: How to get off without protein kinase
                               CK2: the survival strategy of CK2 knockout cells
  • 14:30 – 15:00  Eric S. Fischer: Large Scale Proteomics Approaches
                                to Accelerate Degrader Development for Kinases
                                and other Challenging Targets in Cancer
  • 15:00 – 15:30  Nicholas Kwiatkowski: Selective CDK Inhibitors and
                               Degraders

 

15:30 – 16:00         Coffee break

 

Kinase target biology                                                                            
16:00-17:30

Chair: Alexndra Newton

  • 16:00 – 16:30  Sandhya S. Visweswariah: Pseudokinase domain in
                                receptor GCs
  • 16:30 – 17:00  Short talk
  • 17:00 – 17:30  Richard Bayliss: The Ys and the wherefores of kinase
                               autoinhibition.

 

18:00 – 21:00   poster session and refreshments or Excursion
                              with dinner

 

 

Wednesday, September 18, 2019

Kinase Drug Discovery                                                                         
8:30 – 10:30

Chair: Doriano Fabbro

  • 08:30 – 09:00  Natarajan Kannan: Evolution of allosteric regulation
                               in tyrosine kinases and implications for
                               personalized medicine
  • 09:00 – 09:30  Short Talk   
  • 09:30 – 10:00  Stefan Knapp: Strategies for the rational  design of
                               selective kinase inhibitors kinase structure and
                               chemical probes for untapped kinases
  • 10:00 – 10:30  Doriano Fabbro:  Serendipity and Kinase Drug
                               Discovery    

 

10:30 – 11:00         Coffee Break

 

Kinase Drug Discovery                                                                       
11:00 – 13:00

Chair: Doriano Fabbro

  • 11:00 – 11:30  Sajan JosephTitle   
  • 11:30 – 12:00  Matthias Wymann: Precision drugs – novel tools to
                               target PI3K-mTOR pathways in metabolism and
                               cancer
  • 12:00 – 12:30  Short Talk
  • 12:30 – 13:00  Stefan Laufer: Targeting the R-Spine: Design,
                               Synthesis and Biological Evaluation of Novel Type
                               38α MAP Kinase Inhibitors: Implication for Cancer
                               and CNS

 

13:00 – 14:00   Lunch (Meeting of international and local
                             organizing committees)

 

Kinase Drug Discovery                                                                       
14:00 – 16:00

Chair: Stefan Knapp

  • 14:00 – 14:30 Joanna Niemiec:  Trastuzumab in adjuvant setting
                              applied for HER-2 positive breast cancer patients-
                              Cracov experience
  • 14:30 – 15:00 Cezary Szczylik: Kinase inhibitors in treating Kindey
                              Cancer
  • 15:00 – 15:30 Dario Alessi: Regulation and function of the LRRK2
                              Parkinson’s disease protein kinase
  • 15:30 – 16:00 Natalia Jura: Her4/Her3 interactions

 

16:00 – 16:30         Coffee break

 

Challenges in molecular and structural biology for Kinase Targets      
16
:00 – 18:30

Chair: Susan Taylor

  • 16:30 – 17.00  Jolanta Jura: MAP- kinase dependent regulation of
                               transcripts stability triggered by MCPIP
  • 17:00 – 17:30  Attila Remenyi: Title TBA
  • 17:30 – 18:00  Olga Mayans:  Title TBA

 

18:00 – 21:00   Excursion with dinner

 

Thursday, September 19, 2019

Kinase Biology                                                                                      
09:00 – 13:00

Chair: Andrew Towbin

  • 09:00 – 09:30  Ronit Ilouz: Title
  • 09:30 – 10:00  Anna Marusiak: MLK4 – a new player in breast
                               cancer progression
  • 10:00 – 10:30  Toshiya Senda: A lipid kinase serving as a GTP  sensor in cells
  • 10:30 – 11:15  Tony Hunter: Keynote IUMBM JubileeLecture:
                               Phosphorylation as a paradigm for reversible post-
                               translational modification of proteins (tentative
                               title)
       
  • 11:15 – 11:45  Prizes for best poster presentations.
  • 11:45 – 12:15  Closing remarks  

 

12:15 – 14:00   Lunch (Meeting of international and local
                              organizing committees)

Comments are closed